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Dr Mark Williams

Positions held:
  • Senior Lecturer, School of Natural Sciences
  • Director, ISMB BiophysX Centre; School of Natural Sciences
Email
  • Overview

    Overview

    Highlights

    • A collaboration with Christine Orengo's lab, reveals , the enzyme that fixes CO2 in plants.

    • We are part of - the new European infrastructure for molecular-scale biophysics funded by and dedicated to improving access to, and standards of, measurements of biomolecular function.

    • Our analysis on the controversial topic of enthalpy-entropy compensation shows, for the first time,

    • A collaboration with scientists at the Institute of Cancer Research i, which regulates chromosome separation during cell division

    Web profiles

    Professional memberships

    • Fellow of the Higher Education Academy

    ORCID

  • Research

    Research

    Research interests

    • Biolmolecular Stucture and Thermodynamics
    • Protein-Protein Interactions
    • Protein Structure
    • Bacterial Cell Division
    • Methods for Biomolecular Interaction Measurement
    • Molecular Simulation Methods and Applications

    Research overview

    Research in my group aims to apply a multi-disciplinary approach using biophysical and structural experimental methods, structural bioinformatic analysis and physics-based molecular simulation to develop an integrated understanding of the formation of biomolecular complexes. In addition to working on specific biological systems, e.g. in bacterial cell division, we are聽 developing methods for measurement, data analysis and simulation of interactions.

    Research Centres and Institutes

    • Director of ISMB BiophysX,

    Research clusters and groups

    • Leader of WP3 - Standards in Biophysics,
    • co-Leader WP4 Data Standards and Exploitation,

    Research projects

    MOlecular-Scale Biophysics Research Infrastructure.

    Abstract

    The aim of the MOlecular-Scale Biophysics Research Infrastructure (MOSBRI) is to enable integrative multi-technological studies of biological systems at the crucial intermediate level between atomic-resolution structural descriptions and cellular-scale observations. MOSBRI provides European academic and industrial researchers with Trans-National Access to the latest technological developments in advanced spectroscopies, hydrodynamics, thermodynamics, real-time kinetics and single molecule approaches at the consortium laboratories.

    The consortium of 13 academic centres of excellence and 2 companies from 11 European countries will also play a major role in standardization and policy-making in the field via Joint Research Activities to develop innovative methodologies; designing robust quality control guidelines; FAIR data archiving formats and databases; and contributing to the emergence of a highly qualified new generation of scientists.

  • Supervision and teaching

    Supervision and teaching

    Supervision

    Supervisions within 糖心logo入口:
    1

    Students interested in joining the group for PhD research should usually apply through in which the ISMB is involved.

    Current doctoral researchers

    • RACHEL ALCRAFT
      Nature of supervision:
      PRINCIPAL SUPERVISOR,
      Title of thesis:
      Super-resolution imaging of protein structures

    Teaching

    I am Programme Director for the and my principle teaching duties are related to core modules of the MSc and MRes Bioinformatics.

    Teaching modules

    • The Molecular Basis of Life
    • Statistics and Data Science
  • Publications

    Publications

    Article

    • Agerschou, E.D. and Prchalova, T. and Simek, M. and Mal媒, M. and Stransky, J. and Strnad, M. and Santisteban-Veiga, A. and Williams, Mark and Sab铆n, J. and Dohn谩lek, J. (2025) . European Biophysics Journal ISSN 0175-7571.
    • Muselmani, Wael and Kashif-Khan, Naail and Bagneris, Claire and Santangelo, Rosalia and Williams, Mark A and Savva, Renos (2023) . Viruses 15 (6), ISSN 1999-4915.
    • Paketuryt臈, V. and Petrauskas, V. and Zubrien臈, A. and Abian, O. and Bastos, M. and Chen, W.-Y. and Moreno, M.J. and Krainer, G. and Linkuvien臈, V. and Sedivy, A. and Velazquez-Campoy, A. and Williams, Mark A. and Matulis, D. (2021) . European Biophysics Journal with Biophysics letters 50, pp. 661-670. ISSN 0175-7571.
    • Lopez-Mendes, B. and Baron, B. and Brautigam, C.A. and Jowitt, T.A. and Knauer, S.H. and Uebel, S. and Williams, Mark and Sedivy, A. (2021) . European Biophysics Journal with Biophysics letters 50, pp. 411-427. ISSN 0175-7571.
    • Sivalingam, G.N. and Cryar, A. and Williams, Mark A. and Gooptu, Bibekbrata and Thalassinos, Konstantinos (2018) . International Journal of Mass Spectrometry 426, pp. 29-37. ISSN 1387-3806.
    • Studer, R. A. and Christin, P.-A. and Williams, Mark A. and Orengo, C.A. (2014) . Proceedings of the National Academy of Sciences of the United States of America 111 (6), pp. 2223-2228. ISSN 0027-8424.
    • Olsson, T.S.G. and Pitt, W.R. and Ladbury, J.E. and Williams, Mark A. (2011) . Protein Science 20 (9), pp. 1607-1618. ISSN 0961-8368.
    • da Fonsceca, P.C.A. and Kong, E.H. and Zhang, Z. and Schreiber, A. and Williams, Mark A. and Morris, E.P. and Barford, D. (2011) . Nature 470, pp. 274-278. ISSN 0028-0836.
    • Nilapwar, S. and Williams, E. and Fu, C. and Prodromou, C. and Pearl, L.H. and Williams, Mark A. and Ladbury, J.E. (2009) . Journal of Molecular Biology 392 (4), pp. 923-936. ISSN 0022-2836.
    • Nilapwar, S. and Smith, E.P. and Fu, C. and Prodromou, C. and Pearl, L.H. and Williams, Mark A. and Ladbury, J.E. (2009) . Journal of Molecular Biology 392 (4), pp. 923-936. ISSN 0022-2836.
    • Olsson, T.S.G. and Williams, Mark A. and Pitt, W.R. and Ladbury, J.E. (2008) . Journal of Molecular Biology 384 (4), pp. 1002-1017. ISSN 0022-2836.

    Book section

    • Williams, Mark A. (2017) . In: Lide, D.R. (ed.) CRC Handbook of Chemistry and Physics, 98th Edition. Florida, U.S.: CRC Press. ISBN 9781498784542.
    • Williams, Mark A. (2013) . In: Williams, Mark A. and Daviter, Tina (eds.) Protein鈥揕igand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 3-34. ISSN 1940-6029. ISBN 9781627033978.
    • Daviter, Tina and Fronzes, Remi (2013) . In: Williams, Mark A. and Daviter, Tina (eds.) Protein鈥揕igand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 35-62. ISSN 1940-6029. ISBN 9781627033978.
    • Lowe, P.N. and Vaughan, Cara K. and Daviter, Tina (2013) . In: Williams, Mark A. and Daviter, Tina (eds.) Protein鈥揕igand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 63-99. ISSN 1940-6029. ISBN 9781627033978.
    • Daviter, Tina and Chmel, N. and Rodger, A. (2013) . In: Williams, Mark A. and Daviter, Tina (eds.) Protein鈥揕igand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 211-241. ISSN 1940-6029. ISBN 9781627033978.
    • Turnbull, Andrew P. and Emsley, P. (2013) . In: Williams, Mark A. and Daviter, Tina (eds.) Protein鈥揕igand Interactions: Fundamentals. Methods in Molecular Biology. Berlin, Germany: Springer. pp. 457-477. ISSN 1940-6029. ISBN 9781627033978.
  • Business and community

    Business and community

    Outreach

    Rosalind Franklin Centenary celebrations -



    Services

    • Other
      2021-07-01T00:00:00 to 2025-06-30T00:00:00

      Collaborative research on software development for biomolecular interaction analysis with Affinimeter (Software4Science S.A.)